High-Performance Crossflow Filtration System for Process Development

Evolving operational conditions are the order of the day in today’s biotech labs. That’s why Sartorius Stedim Biotech developed the SARTOFLOW Alpha plus — the flexible, modular benchtop crossflow filtration system. SARTOFLOW Alpha plus provides semi-automatic micro, ultra and diafiltration and is especially suited for process development, clinical testing and for smaller production processes. Thanks to its standardized options, the system can be adapted quickly and easily to the changing production demands of downstream processing. The unique SIP (steam-in-place) module enables aseptic processing and, for such applications, heat-resistant Sartocon filter cassettes are available, along with custom-built valves and sterile connectors. This makes in situ sterilization of the entire system possible. The SARTOFLOW Alpha plus system is cGMP-compliant and self-draining.

The system operates with either disposable bag technology or a permanently installed tank. With its modularity and wide range of accessories, the system is extremely flexible; it is equipped with a well-established DCU4 control module, which faciliates communication with SCADA MFCS/WIN data logging and control software and makes integration with existing networks effortless. The filter holder accommodates up to five Sartocon Slice cassettes, each of which has a filter surface of 0.1 m2 and, because of its IP54 rating (for the pump and the control module), the whole system can be used in refrigerated rooms and rough production climates. The system is easy to install, needing only an electrical connection, access to cooling water and, optionally, a steam generator. Other components, such as compressed air, are not required (www.sartorius.com).